m-PEG2-Amino

• CAT Number: I014049
• CAS Number: 54149-49-4
• Molecular Formula: C5H13NO3
• Molecular Weight: 135.16
• Purity: ≥95%
• Synonyms: O-[2-(2-methoxyethoxy)ethyl]hydroxylamine
• InChI: InChI=1S/C5H13NO3/c1-7-2-3-8-4-5-9-6/h2-6H2,1H3
• InChIKey: VKTXNKVXALMHFI-UHFFFAOYSA-N
• SMILES: COCCOCCON

m-PEG2-Amino is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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