m-PEG12-acid

• CAT Number: I016227
• CAS Number: 2135793-73-4
• Molecular Formula: C26H52O14
• Molecular Weight: 588.68
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C26H52O14/c1-29-4-5-31-8-9-33-12-13-35-16-17-37-20-21-39-24-25-40-23-22-38-19-18-36-15-14-34-11-10-32-7-6-30-3-2-26(27)28/h2-25H2,1H3,(H,27,28)
• InChIKey: JMAKFNFKUHXFBH-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

m-PEG12-acid(CAT: I016227) is a monodisperse polyethylene glycol (PEG) linker terminated with a free carboxylic acid group. Featuring a 12-unit PEG chain, this hydrophilic spacer enhances solubility, reduces steric hindrance, and improves biocompatibility in conjugation strategies. The terminal acid group provides a versatile handle for coupling to amines or other nucleophiles through amide bond formation, making it valuable for the synthesis of inhibitors, antibody–drug conjugates, and targeted delivery systems. With its defined length and flexibility, m-PEG12-acid enables precise spacing between bioactive molecules, optimizing pharmacokinetic properties and minimizing off-target interactions in cancer, metabolic, and immunological disease research.