For research use only. Not for therapeutic Use.
LY3372689（Cat No.:I044043）is a potent and selective inhibitor of enhancer of zeste homolog 2 (EZH2), a key epigenetic regulator and catalytic subunit of the polycomb repressive complex 2 (PRC2). By blocking EZH2 activity, LY3372689 reduces trimethylation of histone H3 on lysine 27 (H3K27me3), leading to reactivation of silenced tumor suppressor genes and modulation of transcriptional programs. It is particularly valuable in cancer research, especially in malignancies driven by EZH2 overexpression or mutations, such as certain lymphomas. LY3372689 offers a promising tool for studying epigenetic therapies and chromatin remodeling in oncology.
| CAS Number | 2241514-56-5 |
| Synonyms | N-[4-fluoro-5-[[(2S,4S)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]piperidin-1-yl]methyl]-1,3-thiazol-2-yl]acetamide |
| Molecular Formula | C16H22FN5O3S |
| Purity | ≥95% |
| IUPAC Name | N-[4-fluoro-5-[[(2S,4S)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]piperidin-1-yl]methyl]-1,3-thiazol-2-yl]acetamide |
| InChI | InChI=1S/C16H22FN5O3S/c1-9-6-12(24-8-14-19-11(3)25-21-14)4-5-22(9)7-13-15(17)20-16(26-13)18-10(2)23/h9,12H,4-8H2,1-3H3,(H,18,20,23)/t9-,12-/m0/s1 |
| InChIKey | FRVXHWNHGWUTQO-CABZTGNLSA-N |
| SMILES | C[C@H]1C[C@H](CCN1CC2=C(N=C(S2)NC(=O)C)F)OCC3=NOC(=N3)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
