For research use only. Not for therapeutic Use.
LY2444296(CAT: I017338) is an orally bioavailable, high-affinity, and selective short-acting kappa opioid receptor (KOR) antagonist with a Ki of ~1 nM. It demonstrates robust anxiolytic and antidepressant-like effects in preclinical models, including reduced anxiety-like behavior in the elevated plus maze (EPM) test. LY2444296 effectively prevents the behavioral and neuroendocrine effects of the KOR agonist U69,593 and mitigates stress- and cocaine-induced behavioral dysregulation by lowering corticosterone release. With its unique pharmacological profile, LY2444296 serves as a valuable tool for exploring neuropsychiatric disorders, stress-related pathology, addiction biology, and therapeutic strategies targeting the kappa opioid system.
| CAS Number | 1346133-11-6 |
| Synonyms | 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide |
| Molecular Formula | C24H22F2N2O2 |
| Purity | ≥95% |
| IUPAC Name | 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide |
| InChI | InChI=1S/C24H22F2N2O2/c25-19-4-1-3-17(13-19)22-5-2-12-28(22)15-16-6-9-20(10-7-16)30-23-11-8-18(24(27)29)14-21(23)26/h1,3-4,6-11,13-14,22H,2,5,12,15H2,(H2,27,29)/t22-/m0/s1 |
| InChIKey | WHHMECUDUQRPJT-QFIPXVFZSA-N |
| SMILES | C1CC(N(C1)CC2=CC=C(C=C2)OC3=C(C=C(C=C3)C(=O)N)F)C4=CC(=CC=C4)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
