LY117018

• CAT Number: R045570
• CAS Number: 63676-25-5
• Molecular Formula: C27H25NO4S
• Molecular Weight: 459.56
• Purity: ≥95%
• Synonyms: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
• InChI: InChI=1S/C27H25NO4S/c29-20-7-3-19(4-8-20)27-25(23-12-9-21(30)17-24(23)33-27)26(31)18-5-10-22(11-6-18)32-16-15-28-13-1-2-14-28/h3-12,17,29-30H,1-2,13-16H2
• InChIKey: JLERVPBPJHKRBJ-UHFFFAOYSA-N
• SMILES: C1CCN(C1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O

LY117018(CAT: R045570) is a Raloxifene analog and selective estrogen receptor modulator (SERM) with demonstrated antiproliferative effects on breast cancer cell lines. In MCF-7 cells, LY117018 inhibits proliferation with an IC₅₀ of 1 μM (96 h). At low concentrations (0.01–10 nM), it mimics estrogen (E2) by elevating p53 levels, while higher concentrations (1 μM) reduce p53 and promote hypophosphorylated pRb. LY117018 also prevents oxidative stress-induced endothelial apoptosis through ERK1/2 signaling activation, highlighting its cytoprotective role. Its dual actions on estrogen receptor pathways and cell survival mechanisms make LY117018 a valuable research tool in cancer biology and vascular health studies.