For research use only. Not for therapeutic Use.
LY-404187（Cat No.:I007854）is a potent, selective positive allosteric modulator of AMPA receptors, enhancing glutamatergic neurotransmission by prolonging receptor channel opening. Developed by Eli Lilly, it is used to study synaptic plasticity, cognition, and memory processes. By amplifying excitatory signaling, LY-404187 provides insights into mechanisms of learning and neurological function. It has been investigated in models of schizophrenia, depression, and neurodegenerative diseases, where AMPA receptor modulation may offer therapeutic benefits. Its pharmacological profile makes it a valuable tool for neuroscience and psychiatric research.
| CAS Number | 211311-95-4 |
| Synonyms | N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide |
| Molecular Formula | C19H22N2O2S |
| Purity | ≥95% |
| IUPAC Name | N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide |
| InChI | InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3 |
| InChIKey | HOQAVGZLYRYHSO-UHFFFAOYSA-N |
| SMILES | CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
