For research use only. Not for therapeutic Use.
LY367385(CAT: R014376) is a selective metabotropic glutamate receptor subtype 1a (mGlu1a) antagonist, known for its ability to block quisqualate-induced phosphoinositide hydrolysis with an IC₅₀ of 8.8 μM. By inhibiting mGlu1a activity, LY367385 modulates glutamatergic neurotransmission without significantly affecting other mGlu receptor subtypes, making it a valuable pharmacological tool for studying mGlu1-mediated signaling pathways. It is widely used in neuroscience research to investigate the role of mGlu1 receptors in synaptic plasticity, pain perception, motor control, and neurodegenerative diseases. Its selectivity and defined mechanism of action make it important for dissecting glutamate receptor functions and exploring potential therapeutic targets.
| CAS Number | 198419-91-9 |
| Synonyms | (S)-α-Amino-4-carboxy-2-methylbenzeneacetic Acid?(S)-2-Methyl-4-carboxyphenylglycine; |
| Molecular Formula | C10H11NO4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 100 mM in 1.1eq. NaOH |
| Storage | Desiccate at RT |
| IUPAC Name | 4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid |
| InChI | InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1 |
| InChIKey | SGIKDIUCJAUSRD-QMMMGPOBSA-N |
| SMILES | CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
