LY 303511 hydrochloride

• CAT Number: I005869
• CAS Number: 2070014-90-1
• Molecular Formula: C19H19ClN2O2
• Molecular Weight: 342.82
• Purity: ≥95%
• Target: mTOR
• Solubility: DMSO: ≥ 45 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 8-phenyl-2-piperazin-1-ylchromen-4-one;hydrochloride
• InChI: InChI=1S/C19H18N2O2.ClH/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14;/h1-8,13,20H,9-12H2;1H
• InChIKey: QGVSIVYHHKLHPY-UHFFFAOYSA-N

in vivo: PND4 ovaries were cultured for 8 days in control medium or medium containing VCD (30 μM) in the presence or absence of LY303511 (20 μM). Incubation with LY303511 alone caused a reduction (P < 0.05) in primordial and small primary follicle numbers. On the other hand, whereas VCD alone depleted (P < 0.05) primordial and small primary follicle numbers, this depletion was not prevented by co-incubation with LY303511.

Reference

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[2]. El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 2003 Apr;17(6):720-2. 


[3]. Bodenstine TM, Vaidya KS, Ismail A, Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70(23):10002-11. 


[4]. Keating AF, J Mark C, Sen N, Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries. Toxicol Appl Pharmacol. 2009 Dec 1;241(2):127-34.