Luzindole

• CAT Number: R000851
• CAS Number: 117946-91-5
• Molecular Formula: C19H20N2O
• Molecular Weight: 292.37
• Purity: ≥95%
• Synonyms: N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide
• InChI: InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
• InChIKey: WVVXBPKOIZGVNS-UHFFFAOYSA-N
• SMILES: CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3

Luzindole (CAT: R000851) is a selective melatonin receptor antagonist with preferential activity toward MT₂ (Mel1b) over MT₁ (Mel1a) receptors, exhibiting Ki values of 10.2 nM and 158 nM, respectively. It is widely used in circadian rhythm, neuroimmunology, and mood regulation research. In vitro, Luzindole inhibits antigen-specific proliferation of MBP-reactive T cells, while in vivo it suppresses experimental autoimmune encephalomyelitis (EAE). Additionally, Luzindole shows antidepressant-like effects, reducing immobility time in behavioral assays in a dose- and time-dependent manner. These properties make Luzindole a valuable pharmacological tool for dissecting melatonin receptor signaling in neuroinflammation, depression, and circadian biology.