Lu AE98134

• CAT Number: I045353
• CAS Number: 849000-18-6
• Molecular Formula: C21H23N5O3S
• Molecular Weight: 425.50
• Purity: ≥95%
• Synonyms: N-butyl-4-methoxy-3-(6-methyl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide
• InChI: InChI=1S/C21H23N5O3S/c1-4-5-12-22-30(27,28)15-10-11-19(29-3)18(13-15)21-24-23-20-17-9-7-6-8-16(17)14(2)25-26(20)21/h6-11,13,22H,4-5,12H2,1-3H3
• InChIKey: KLTJHVNRXQKMLY-UHFFFAOYSA-N
• SMILES: CCCCNS(=O)(=O)C1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(C4=CC=CC=C43)C

Lu AE98134 (Cat No.: I045353) is a selective neurokinin-3 receptor (NK3R) antagonist developed for the treatment of psychiatric and neurological disorders. By blocking NK3R, which is activated by neurokinin B, Lu AE98134 modulates central nervous system pathways involved in mood regulation, stress response, and reproductive hormone control. It has been investigated for potential use in treating conditions such as schizophrenia, hot flashes, and mood disorders. Lu AE98134 serves as a valuable tool for exploring tachykinin receptor biology and developing targeted neuropsychiatric therapies.

Reference

[1]. Nadia Lybøl von Schoubye, et al. The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6 +/- mice. Neurosci Lett. 2018 Jan 1;662:29-35.
[Content Brief]