For research use only. Not for therapeutic Use.
LU-005i(CAT: I040619) is a potent and selective inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic enzyme involved in histone demethylation and transcriptional regulation. By blocking LSD1 activity, LU-005i modulates gene expression programs related to stemness, differentiation, and oncogenesis, making it a valuable tool for studying epigenetic control in cancer, particularly acute myeloid leukemia (AML) and solid tumors. It is also relevant in neurodevelopmental and neurodegenerative research due to LSD1’s role in neuronal gene regulation. LU-005i enables investigation of chromatin dynamics and therapeutic targeting of epigenetic enzymes, supporting applications in cancer biology, regenerative medicine, and epigenetic drug discovery.
| CAS Number | 1620107-33-6 |
| Synonyms | (2S)-N-[(2S)-3-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide |
| Molecular Formula | C31H46N4O7 |
| Purity | ≥95% |
| IUPAC Name | (2S)-N-[(2S)-3-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide |
| InChI | InChI=1S/C31H46N4O7/c1-21(32-27(36)19-35-13-15-41-16-14-35)29(38)34-26(18-23-9-11-24(40-3)12-10-23)30(39)33-25(28(37)31(2)20-42-31)17-22-7-5-4-6-8-22/h9-12,21-22,25-26H,4-8,13-20H2,1-3H3,(H,32,36)(H,33,39)(H,34,38)/t21-,25-,26-,31+/m0/s1 |
| InChIKey | UHNYITHLNFUAIN-VTNASVEKSA-N |
| SMILES | CC(C(=O)NC(CC1=CC=C(C=C1)OC)C(=O)NC(CC2CCCCC2)C(=O)C3(CO3)C)NC(=O)CN4CCOCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
