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CAS No.: 1234480-84-2
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| Product Details | |
|---|---|
For research use only. Not Intended for Therapeutic Use! |
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| Cat No: | I000932 |
| Synonyms: | 2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Molecular Formula: | C31H38N8O3 |
| Molecular Weight: | 570.7 |
| IC50:: | 13 nM (wild type); 6 nM (G2019S mutant); 2.45 μM (drug resistant A2016T mutant LRRK2) |
| Description: | LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. IC50 is 13 nM, 6 nM, and 2.45 μM for wild type, G2019S mutant, and drug resistant A2016T mutant LRRK2, respectively. |
| Price: | Get quote |
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LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. IC50 is 13 nM, 6 nM, and 2.45 μM for wild type, G2019S mutant, and drug resistant A2016T mutant LRRK2, respectively.
IC50 Value: 13 nM (wild type); 6 nM (G2019S mutant); 2.45 μM (drug resistant A2016T mutant LRRK2)
Target: LRRK2; Mutant LRRK2
LRRK2-IN-1 is useful in treatment of Parkinson/’s disease.
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