For research use only. Not for therapeutic Use.
LpxH-IN-AZ1(CAT: I016925) is a sulfonyl piperazine compound that functions as a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase (LpxH), a key enzyme in lipid A biosynthesis. It exhibits strong activity against Klebsiella pneumoniae LpxH with an IC₅₀ of 0.36 μM and against Escherichia coli LpxH with an IC₅₀ of 0.14 μM. At 1 μM, LpxH-IN-AZ1 inhibits 75% of K. pneumoniae LpxH and 83% of E. coli LpxH activity in the presence of 100 μM UDP-DAGn. This compound is a valuable tool for studying bacterial cell wall biosynthesis and for exploring novel antibacterial therapeutic strategies.
| CAS Number | 901260-40-0 |
| Synonyms | 1-[5-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonyl-2,3-dihydroindol-1-yl]ethanone |
| Molecular Formula | C21H22F3N3O3S |
| Purity | ≥95% |
| IUPAC Name | 1-[5-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonyl-2,3-dihydroindol-1-yl]ethanone |
| InChI | InChI=1S/C21H22F3N3O3S/c1-15(28)27-8-7-16-13-19(5-6-20(16)27)31(29,30)26-11-9-25(10-12-26)18-4-2-3-17(14-18)21(22,23)24/h2-6,13-14H,7-12H2,1H3 |
| InChIKey | JRTCXCIMCOKGMN-UHFFFAOYSA-N |
| SMILES | CC(=O)N1CCC2=C1C=CC(=C2)S(=O)(=O)N3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
