For research use only. Not for therapeutic Use.
LP-261（Cat No.:I007713）is an orally bioavailable small-molecule inhibitor targeting tubulin polymerization, thereby disrupting microtubule dynamics essential for mitotic spindle formation and cell division. By binding to the colchicine site on tubulin, LP-261 induces mitotic arrest and apoptosis in rapidly dividing cancer cells. It has shown broad-spectrum antitumor activity in preclinical models, including solid tumors and hematologic malignancies, with favorable pharmacokinetic properties supporting oral dosing. LP-261 is a valuable research tool for studying microtubule function and holds therapeutic potential as an anti-mitotic agent for treating diverse, fast-growing malignancies resistant to conventional therapies.
| CAS Number | 915412-67-8 |
| Synonyms | N-[3-(1H-indol-4-yl)-5-(2-methoxypyridine-4-carbonyl)phenyl]methanesulfonamide |
| Molecular Formula | C22H19N3O4S |
| Purity | ≥95% |
| IUPAC Name | N-[3-(1H-indol-4-yl)-5-(2-methoxypyridine-4-carbonyl)phenyl]methanesulfonamide |
| InChI | InChI=1S/C22H19N3O4S/c1-29-21-13-14(6-8-24-21)22(26)16-10-15(11-17(12-16)25-30(2,27)28)18-4-3-5-20-19(18)7-9-23-20/h3-13,23,25H,1-2H3 |
| InChIKey | YUVDELGTFILMBB-UHFFFAOYSA-N |
| SMILES | COC1=NC=CC(=C1)C(=O)C2=CC(=CC(=C2)C3=C4C=CNC4=CC=C3)NS(=O)(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
