LP-184

• CAT Number: I044397
• CAS Number: 924835-67-6
• Molecular Formula: C16H20N2O4
• Molecular Weight: 304.34
• Purity: ≥95%
• Synonyms: 1-hydroxy-1-[[(5’R)-5′-hydroxy-2′,5′,7′-trimethyl-4′-oxospiro[cyclopropane-1,6′-indene]-1′-yl]methyl]urea
• IUPAC Name: 1-hydroxy-1-[[(5'R)-5'-hydroxy-2',5',7'-trimethyl-4'-oxospiro[cyclopropane-1,6'-indene]-1'-yl]methyl]urea
• InChI: InChI=1S/C16H20N2O4/c1-8-6-10-12(11(8)7-18(22)14(17)20)9(2)16(4-5-16)15(3,21)13(10)19/h6,21-22H,4-5,7H2,1-3H3,(H2,17,20)/t15-/m0/s1
• InChIKey: VWMPVAZEBAKLFR-HNNXBMFYSA-N
• SMILES: CC1=C(C2=C(C3(CC3)[C@@](C(=O)C2=C1)(C)O)C)CN(C(=O)N)O

LP-184（Cat No.:I044397）is a novel, alkylating anticancer agent belonging to the acylfulvene class, designed to selectively target tumors with specific DNA repair deficiencies, such as those with PTGR1 overexpression or HR (homologous recombination) repair defects. It induces DNA damage leading to apoptosis, particularly in cancers with high oxidative stress or impaired repair pathways. LP-184 exhibits potent cytotoxicity in preclinical models of pancreatic, prostate, and brain cancers. Its mechanism allows for precision oncology approaches, offering therapeutic potential for hard-to-treat tumors, including those resistant to conventional chemotherapies or with specific genetic vulnerabilities.