LOX-IN-3 dihydrochloride

• CAT Number: I044596
• CAS Number: 2409964-23-2
• Molecular Formula: C13H15Cl2FN2O2S
• Molecular Weight: 353.24
• Purity: ≥95%
• Synonyms: (Z)-3-fluoro-4-quinolin-8-ylsulfonylbut-2-en-1-amine;dihydrochloride
• InChI: InChI=1S/C13H13FN2O2S.2ClH/c14-11(6-7-15)9-19(17,18)12-5-1-3-10-4-2-8-16-13(10)12;;/h1-6,8H,7,9,15H2;2*1H/b11-6-
• InChIKey: YYYHSAUHJBNINZ-LEOXJOGCSA-N
• SMILES: C1=CC2=C(C(=C1)S(=O)(=O)C/C(=C/CN)/F)N=CC=C2.Cl.Cl

LOX-IN-3 dihydrochloride（Cat No.:I044596）is a potent and selective inhibitor of lysyl oxidase (LOX), an enzyme critical for the cross-linking of collagen and elastin in the extracellular matrix. By blocking LOX activity, LOX-IN-3 dihydrochloride interferes with extracellular matrix remodeling, a key process in tumor progression, fibrosis, and metastasis. This compound has demonstrated strong anti-fibrotic and anti-tumor properties in preclinical studies. The dihydrochloride salt form enhances its solubility and stability for research use. LOX-IN-3 dihydrochloride is valuable for investigating LOX’s role in cancer biology, tissue stiffness, and fibrotic disease mechanisms.