Lovastatin hydroxy acid sodium

• CAT Number: R001753
• CAS Number: 75225-50-2
• Molecular Formula: C24H37NaO6
• Molecular Weight: 444.54
• Purity: ≥95%
• Synonyms: sodium;(3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• InChI: InChI=1S/C24H38O6.Na/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28;/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-4H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,18+,19+,20-,21-,23-;/m0./s1
• InChIKey: LXZBFUBRYYVRQJ-AXHZAXLDSA-M
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O)C.[Na+]

Lovastatin hydroxy acid sodium（Cat No.:R001753）is the active, open-ring hydrolyzed form of lovastatin, belonging to the statin class of lipid-lowering agents. As a sodium salt, it enhances solubility and stability for research applications. This compound functions as a potent competitive inhibitor of HMG-CoA reductase, the key enzyme in the mevalonate pathway responsible for cholesterol biosynthesis. By reducing intracellular cholesterol levels, it influences lipid metabolism, cardiovascular health, and cellular signaling. In research, lovastatin hydroxy acid sodium is used to study cholesterol regulation, atherosclerosis mechanisms, and potential therapeutic strategies for metabolic disorders.