Loteprednol

• CAT Number: M117846
• CAS Number: 129260-79-3
• Molecular Formula: C21H27ClO5
• Molecular Weight: 394.89
• Purity: ≥95%
• Storage: Desiccate at -20C
• IUPAC Name: chloromethyl (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
• InChI: InChI=1S/C21H27ClO5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,18(25)27-11-22)20(15,2)10-16(24)17(14)19/h5,7,9,14-17,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,17+,19-,20-,21-/m0/s1
• InChIKey: YPZVAYHNBBHPTO-MXRBDKCISA-N
• SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)OCCl)O)CCC4=CC(=O)C=C[C@]34C)O

Loteprednol（Cat No.:M117846）is a corticosteroid medication primarily used to treat inflammatory conditions of the eye, such as allergic conjunctivitis, uveitis, and post-operative inflammation. Structurally derived from prednisolone, it is designed using retrometabolic drug design to be active locally and rapidly deactivated upon systemic absorption, minimizing side effects. Loteprednol etabonate, its commonly used ester form, exhibits strong anti-inflammatory activity with reduced risk of intraocular pressure elevation compared to other steroids. It is available in ophthalmic formulations like drops, gels, and ointments for safe, targeted, and effective ocular therapy.