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LOBAPLATIN

LOBAPLATIN

  • CAT Number: M112322
  • CAS Number: 135558-11-1
  • Molecular Formula: C9H18N2O3Pt
  • Molecular Weight: 397.33
  • Purity: ≥95%
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Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Its antitumour activity results from the formation of DNA-drug adducts, mainly as GG and AG intra-strand cross-links. Lobaplatin influences the expression of the c-myc gene, which is involved in oncogenesis, apoptosis and cell proliferation. Lobaplatin has activity in a wide range of preclinical tumour models and appears to overcome tumour resistance to cisplatin and carboplatin in some of these models. In the body, lobaplatin remains largely intact until removed by glomerular filtration. (source: Expert Opin Investig Drugs. 2001 Jan;10(1):119-28.).

Catalog Number M112322
CAS Number 135558-11-1
Molecular Formula

C9H18N2O3Pt

Purity 95%
Storage -20°C
Reference

</br>1:Simple on-line pretreatment of column-switching coupled with ion chromatography for the determination of lactic acid in lobaplatin. Zhao Z, Zhu J, Xie Y.J Pharm Biomed Anal. 2017 May 10;138:316-321. doi: 10.1016/j.jpba.2017.02.031. Epub 2017 Feb 20. PMID: 28242572 </br>2:Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial. Ke LR, Xia WX, Qiu WZ, Huang XJ, Yang J, Yu YH, Liang H, Liu GY, Ye YF, Xiang YQ, Guo X, Lv X.BMC Cancer. 2017 Feb 15;17(1):134. doi: 10.1186/s12885-017-3080-4. PMID: 28202000 Free PMC Article</br>3:Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS- mitochondrial apoptotic pathway and impairs cell migration and invasion. Li Y, Liu B, Yang F, Yu Y, Zeng A, Ye T, Yin W, Xie Y, Fu Z, Zhao C.Biomed Pharmacother. 2016 Oct;83:1239-1246. doi: 10.1016/j.biopha.2016.08.053. Epub 2016 Aug 24. PMID: 27565846 </br>4:Re: Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center, Eur J Surg Oncol (2016). Kim JW, Choi SH.Eur J Surg Oncol. 2016 Nov;42(11):1760-1761. doi: 10.1016/j.ejso.2016.06.406. Epub 2016 Aug 11. No abstract available. PMID: 27683051 </br>5:Reply to: Re: Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center, Eur J Surg Oncol (2016). Wu HT, Li Y.Eur J Surg Oncol. 2016 Nov;42(11):1762-1766. doi: 10.1016/j.ejso.2016.06.405. Epub 2016 Aug 12. No abstract available. PMID: 27567099 </br>6:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies. Wu HT, Yang XJ, Huang CQ, Sun JH, Ji ZH, Peng KW, Zhang Q, Li Y.World J Surg Oncol. 2016 Sep 15;14(1):246. doi: 10.1186/s12957-016-1004-4. PMID: 27633880 Free PMC Article</br>7:Lobaplatin for the treatment of SK-MES-1 lung squamous cell line in vitro and in vivo. Zhang H, Chen R, Yang S, Liu W, Li K, Zhang H, Zhu X, Chen B.Onco Targets Ther. 2016 Jul 11;9:4215-24. doi: 10.2147/OTT.S108032. eCollection 2016. PMID: 27471396 Free PMC Article</br>8:[Inhibitory effect of imrecoxib combined with lobaplatin on tumor growth and lymph node metastasis of human lung cancer xenografts in nude mice]. Wang DC, Wang LC, Wang LJ, Chen G, Zhao YX, Zhao ZF, Li YH.Zhonghua Zhong Liu Za Zhi. 2016 May 23;38(5):340-5. doi: 10.3760/cma.j.issn.0253-3766.2016.05.004. Chinese. PMID: 27188605 </br>9:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center. Wu HT, Peng KW, Ji ZH, Sun JH, Zhang Q, Yang XJ, Huang CQ, Li Y.Eur J Surg Oncol. 2016 Jul;42(7):1024-34. doi: 10.1016/j.ejso.2016.04.053. Epub 2016 May 3. PMID: 27179924 Free Article</br>10:An open-label, single-arm phase II clinical study of docetaxel plus lobaplatin for Chinese patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma. Zhang S, Chen J, Yang S, Lin S.Anticancer Drugs. 2016 Aug;27(7):685-8. doi: 10.1097/CAD.0000000000000370. PMID: 27088576

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