LKY-047

• CAT Number: I045551
• CAS Number: 1954681-29-8
• Molecular Formula: C23H19NO7
• Molecular Weight: 421.40
• Purity: ≥95%
• Synonyms: [(3S)-2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g]chromen-3-yl] (E)-3-(4-nitrophenyl)prop-2-enoate
• InChI: InChI=1S/C23H19NO7/c1-23(2)20(30-22(26)9-5-14-3-7-17(8-4-14)24(27)28)12-16-11-15-6-10-21(25)29-18(15)13-19(16)31-23/h3-11,13,20H,12H2,1-2H3/b9-5+/t20-/m0/s1
• InChIKey: AEVGNLMZEXKNKR-MRSBXDGLSA-N
• SMILES: CC1(C(CC2=C(O1)C=C3C(=C2)C=CC(=O)O3)OC(=O)C=CC4=CC=C(C=C4)[N+](=O)[O-])C

LKY-047 (Cat No.: I045551) is a selective small-molecule TRPC3/6 ion channel inhibitor used in research on calcium signaling and related pathophysiology. By blocking TRPC3/6-mediated calcium influx, LKY-047 modulates signaling pathways involved in cardiac hypertrophy, fibrosis, and kidney disease. It has been employed in studies investigating the therapeutic potential of TRPC channel modulation in cardiovascular and renal disorders. With high selectivity and potency, LKY-047 is a valuable tool for exploring TRP channel biology, calcium-dependent signaling mechanisms, and drug discovery targeting ion channels.

Reference

[1]. Nguyen Minh Phuc, et al. LKY-047: First Selective Inhibitor of Cytochrome P450 2J2. Drug Metab Dispos. 2017 Jul;45(7):765-769.
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