Lithocholic acid

• CAT Number: I003548
• CAS Number: 434-13-9
• Molecular Formula: C24H40O3
• Molecular Weight: 376.6
• Purity: ≥95%
• Synonyms: 3ɑ-Hydroxy Cholanic Acid;LCA;Lithocholate;NSC 683770
• Target: Others
• Solubility: DMSO 75 mg/mL; Water <1 mg/mL; Ethanol 49 mg/mL
• Storage: 3 years -20C powder
• InChIKey: SMEROWZSTRWXGI-HVATVPOCSA-N

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity.Target: OthersLithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.

Reference

[1]. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21-6.
[2]. Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2(10): p. 761-82.
[3]. Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707.