Lithocholic acid - CAS 434-13-9

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity.
Target: Others
Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.




Catalog Number: I003548

CAS Number: 434-13-9

PubChem Substance ID:355038887

Molecular Formula: C24H40O3

Molecular Weight:376.6

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms3ɑ-Hydroxy Cholanic Acid;LCA;Lithocholate;NSC 683770

Property

Molecular Formula: C24H40O3
Molecular Weight376.6
Target:Others
SolubilityDMSO 75 mg/mL; Water <1 mg/mL; Ethanol 49 mg/mL
Purity≥95%
Storage3 years -20C powder

Computed Descriptor

InChIKeySMEROWZSTRWXGI-HVATVPOCSA-N