For research use only. Not for therapeutic Use.
Lib2‑1(CAT: I040396) is a macrocyclic peptide that selectively inhibits the interaction between IL‑17C and its receptor IL‑17RE, key modulators in pro‑inflammatory signaling. Its thioether‑bridged cyclic structure confers high binding affinity, stability, and specificity. Lib2‑1 is primarily used in autoimmune and inflammatory disease research, aiding the study of IL‑17C–driven pathways and therapeutic targeting strategies. It is supplied at high purity by leading peptides vendors (e.g., MedChemExpress), and is delivered as a white to off‑white solid. Recommended for in vitro assays and preclinical models, it is ideal for probing IL‑17C biology and validating novel anti‑inflammatory candidates.
| CAS Number | 2983116-47-6 |
| Synonyms | 2-[(3R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42S)-3-[(2-amino-2-oxoethyl)carbamoyl]-36-[(2S)-butan-2-yl]-24-(hydroxymethyl)-18,30,33,42-tetrakis[(4-hydroxyphenyl)methyl]-39-(1H-imidazol-4-ylmethyl)-27-methyl-9,21-bis(2-methylpropyl)-5,8,11,14,17,20,23,26,29,32,35,38,41,44-tetradecaoxo-1-thia-4,7,10,13,16,19,22,25,28,31,34,37,40,43-tetradecazacyclopentatetracont-12-yl]acetic acid |
| Molecular Formula | C81H108N18O23S |
| Purity | ≥95% |
| IUPAC Name | 2-[(3R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42S)-3-[(2-amino-2-oxoethyl)carbamoyl]-36-[(2S)-butan-2-yl]-24-(hydroxymethyl)-18,30,33,42-tetrakis[(4-hydroxyphenyl)methyl]-39-(1H-imidazol-4-ylmethyl)-27-methyl-9,21-bis(2-methylpropyl)-5,8,11,14,17,20,23,26,29,32,35,38,41,44-tetradecaoxo-1-thia-4,7,10,13,16,19,22,25,28,31,34,37,40,43-tetradecazacyclopentatetracont-12-yl]acetic acid |
| InChI | InChI=1S/C81H108N18O23S/c1-8-43(6)69-81(122)97-59(30-48-15-23-53(104)24-16-48)77(118)95-58(29-47-13-21-52(103)22-14-47)74(115)88-44(7)70(111)98-62(37-100)80(121)93-55(26-42(4)5)75(116)94-56(27-45-9-17-50(101)18-10-45)72(113)86-35-65(106)89-61(32-68(109)110)78(119)92-54(25-41(2)3)71(112)85-36-66(107)91-63(73(114)84-34-64(82)105)38-123-39-67(108)90-57(28-46-11-19-51(102)20-12-46)76(117)96-60(79(120)99-69)31-49-33-83-40-87-49/h9-24,33,40-44,54-63,69,100-104H,8,25-32,34-39H2,1-7H3,(H2,82,105)(H,83,87)(H,84,114)(H,85,112)(H,86,113)(H,88,115)(H,89,106)(H,90,108)(H,91,107)(H,92,119)(H,93,121)(H,94,116)(H,95,118)(H,96,117)(H,97,122)(H,98,111)(H,99,120)(H,109,110)/t43-,44-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,69-/m0/s1 |
| InChIKey | GYEUKUWPMQEUMQ-OROZPHLRSA-N |
| SMILES | CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(CSCC(=O)NC(C(=O)NC(C(=O)N1)CC2=CNC=N2)CC3=CC=C(C=C3)O)C(=O)NCC(=O)N)CC(C)C)CC(=O)O)CC4=CC=C(C=C4)O)CC(C)C)CO)C)CC5=CC=C(C=C5)O)CC6=CC=C(C=C6)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
