LGD-3303

  • CAT Number: I011845
  • CAS Number: 917891-35-1
  • Molecular Formula: C16H14ClF3N2O
  • Molecular Weight: 342.746
  • Purity: ≥95%
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LGD-3303(CAT: I011845) is a selective androgen receptor modulator (SARM) with excellent oral bioavailability. It has been studied as a possible treatment for osteoporosis and has been shown in animal studies to improve the effectiveness of bisphosphonate drugs. This product is used for medical research and development and other scientific research purposes.

Catalog Number I011845
CAS Number 917891-35-1
Synonyms

LGD 3303; 9-Chloro-2-ethyl-3,6-dihydro-1-methyl-3-(2,2,2-trifluoroethyl)-7H-pyrrolo[3,2-f]quinolin-7-one;

Molecular Formula

C16H14ClF3N2O

Purity 95%
Target Androgen receptor
Storage RT
Overview of Clinical Research

<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>LGD-3303 is a selective androgen receptor modulator. It has been granted for the new molecular entity.&nbsp;</span></span></span>

IUPAC Name 9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-6H-pyrrolo[3,2-f]quinolin-7-one
InChI InChI=1S/C16H14ClF3N2O/c1-3-11-8(2)14-12(22(11)7-16(18,19)20)5-4-10-15(14)9(17)6-13(23)21-10/h4-6H,3,7H2,1-2H3,(H,21,23)
InChIKey OMXGOGXEWUCLFI-UHFFFAOYSA-N
SMILES CCC1=C(C2=C(N1CC(F)(F)F)C=CC3=C2C(=CC(=O)N3)Cl)C
Reference

1: Vajda EG, L&oacute;pez FJ, Rix P, Hill R, Chen Y, Lee KJ, O/&#39;Brien Z, Chang WY, Meglasson MD, Lee YH. Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7( 6H)-one], an orally available nonsteroidal-selective androgen receptor modulator. J Pharmacol Exp Ther. 2009 Feb;328(2):663-70. doi: 10.1124/jpet.108.146811. Epub 2008 Nov 18. PubMed PMID: 19017848.

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