Levetiracetam

• CAT Number: A000496
• CAS Number: 102767-28-2
• Molecular Formula: C8H14N2O2
• Molecular Weight: 170.21
• Purity: ≥95%
• Synonyms: 102767-28-2; Keppra; (S)-2-(2-Oxopyrrolidin-1-yl)butanamide; Keppra XR; Levetiracetamum
• Storage: -20°C
• IUPAC Name: (2S)-2-(2-oxopyrrolidin-1-yl)butanamide
• InChI: 1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
• InChIKey: HPHUVLMMVZITSG-LURJTMIESA-N
• SMILES: CCC(C(=O)N)N1CCCC1=O

Levetiracetam (Cat No.: A000496) is an anticonvulsant medication used to treat various types of seizures, including partial-onset, myoclonic, and generalized tonic-clonic seizures in both adults and children. Its precise mechanism is not fully understood, but it is believed to modulate synaptic neurotransmitter release by binding to the SV2A protein in the brain. Levetiracetam is available in oral and intravenous forms and is generally well-tolerated. Common side effects include drowsiness, dizziness, and irritability. It has minimal drug interactions, making it suitable for combination therapy.

Reference

1: Dircio-Bautista M, Colín-González AL, Aguilera G, Maya-López M,
Villeda-Hernández J, Galván-Arzate S, García E, Túnez I, Santamaría A. The
Antiepileptic Drug Levetiracetam Protects Against Quinolinic Acid-Induced
Toxicity in the Rat Striatum. Neurotox Res. 2017 Nov 9. doi:
10.1007/s12640-017-9836-4. [Epub ahead of print] PubMed PMID: 29124680.

2: Barnard L, Barnes Heller H, Boothe DM. Pharmacokinetics of Single Oral Dose
Extended-Release Levetiracetam in Healthy Cats. J Vet Intern Med. 2017 Nov 8.
doi: 10.1111/jvim.14863. [Epub ahead of print] PubMed PMID: 29114943.

3: Premoli I, Costantini A, Rivolta D, Biondi A, Richardson MP. The Effect of
Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation
Intensity. Front Neurosci. 2017 Oct 20;11:585. doi: 10.3389/fnins.2017.00585.
eCollection 2017. PubMed PMID: 29104528; PubMed Central PMCID: PMC5655014.

4: Shastay A. Prescribing Errors With LevETIRAcetam Oral Solution. Home Healthc
Now. 2017 Nov/Dec;35(10):571-573. doi: 10.1097/NHH.0000000000000612. PubMed PMID:
29095340.

5: Kanda J, Izumo N, Kobayashi Y, Onodera K, Shimakura T, Yamamoto N, Takahashi
HE, Wakabayashi H. Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and
Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats. Biol Pharm
Bull. 2017;40(11):1934-1940. doi: 10.1248/bpb.b17-00482. PubMed PMID: 29093341.

6: Yan BC, Shen H, Zhang Y, Zhu X, Wang J, Xu P, Jiang D, Yu X. The antiepileptic
drug levetiracetam promotes neuroblast differentiation and expression of
superoxide dismutase in the mouse hippocampal dentate gyrus via PI3K/Akt
signalling. Neurosci Lett. 2017 Oct 9;662:84-90. doi:
10.1016/j.neulet.2017.10.010. [Epub ahead of print] PubMed PMID: 29024726.

7: Feyissa AM. Antiepileptic drug-related neuropsychiatric adverse events in
brain tumor-related epilepsy: levetiracetam front and center. Eur J Neurol. 2017
Sep 30. doi: 10.1111/ene.13399. [Epub ahead of print] PubMed PMID: 28963765.

8: Li XC, Lu LL, Wang JZ, Wang M, Gao Y, Lin YX, Han ZH. Clinical characteristics
and electroencephalogram analysis of levetiracetam in the treatment of children
with febrile seizure recurrence. Exp Ther Med. 2017 Sep;14(3):2015-2020. doi:
10.3892/etm.2017.4738. Epub 2017 Jul 9. PubMed PMID: 28962118; PubMed Central
PMCID: PMC5609163.

9: Kakisaka Y, Jin K, Fujikawa M, Kitazawa Y, Kato K, Nakasato N. Levetiracetam
improves symptoms of multiple chemical sensitivity: Case report. J Med Invest.
2017;64(3.4):296-298. doi: 10.2152/jmi.64.296. PubMed PMID: 28955000.

10: Hau Man TH, Shek-Kwan CR, On-Kei CA, Lam CPW. Effect of plasmapheresis on
serum levels of clobazam, levetiracetam and topiramate. Epilepsy Behav Case Rep.
2017 Jul 19;8:66-68. doi: 10.1016/j.ebcr.2017.07.002. eCollection 2017. PubMed
PMID: 28951835; PubMed Central PMCID: PMC5607118.