LEO 39652

• CAT Number: I045446
• CAS Number: 1445656-91-6
• Molecular Formula: C23H23N3O5
• Molecular Weight: 421.45
• Purity: ≥95%
• Synonyms: 2-methylpropyl 1-[8-methoxy-5-(1-oxo-3H-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate
• InChI: InChI=1S/C23H23N3O5/c1-13(2)11-31-22(28)23(8-9-23)21-24-19-18(29-3)7-6-17(26(19)25-21)14-4-5-16-15(10-14)12-30-20(16)27/h4-7,10,13H,8-9,11-12H2,1-3H3
• InChIKey: LUUUHUYQTLUIDG-UHFFFAOYSA-N
• SMILES: CC(C)COC(=O)C1(CC1)C2=NN3C(=CC=C(C3=N2)OC)C4=CC5=C(C=C4)C(=O)OC5

LEO 39652 (Cat No.: I045446) is a small-molecule inhibitor targeting phosphodiesterase 4 (PDE4), an enzyme responsible for hydrolyzing cyclic AMP (cAMP), thereby regulating inflammatory signaling pathways. By blocking PDE4 activity, LEO 39652 increases intracellular cAMP levels, leading to suppression of pro-inflammatory cytokine production. It is investigated for potential therapeutic applications in dermatological and inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease (COPD). LEO 39652 serves as a research tool for studying cAMP-mediated immune modulation and anti-inflammatory drug development.

Reference

[1]. Jens Larsen, et al. Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Ato
[Content Brief]

[2]. Stefan Eirefelt, et al. Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies. Pharm Res. 2020 Nov 13;37(12):243.
[Content Brief]