Lenalidomide-propargyl-C2-NH2 hydrochloride

• CAT Number: I046009
• CAS Number: 2489242-23-9
• Molecular Formula: C18H20ClN3O3
• Molecular Weight: 361.82
• Purity: ≥95%
• Synonyms: 3-[7-(5-aminopent-1-ynyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;hydrochloride
• InChI: InChI=1S/C18H19N3O3.ClH/c19-10-3-1-2-5-12-6-4-7-13-14(12)11-21(18(13)24)15-8-9-16(22)20-17(15)23;/h4,6-7,15H,1,3,8-11,19H2,(H,20,22,23);1H
• InChIKey: QONOSTNDZFIDAF-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C=CC=C3C2=O)C#CCCCN.Cl

Lenalidomide-propargyl-C2-NH2 hydrochloride(CAT: I046009) is a functionalized lenalidomide-based cereblon (CRBN) E3 ligase ligand modified with a propargyl handle and a short C2-amino linker. Designed as a versatile intermediate for PROTAC (proteolysis-targeting chimera) synthesis, this derivative enables efficient conjugation through bioorthogonal chemistry such as CuAAC click reactions. By retaining high affinity for CRBN, it facilitates targeted ubiquitination and proteasomal degradation of proteins of interest when coupled to appropriate ligands. Lenalidomide-propargyl-C2-NH2 hydrochloride is a valuable tool in chemical biology, targeted protein degradation research, and drug discovery, particularly for applications in oncology, immunology, and epigenetics.