For research use only. Not for therapeutic Use.
Lenalidomide-PEG1-azide(CAT: I016891) is a functionalized cereblon (CRBN) ligand designed for targeted protein degradation research, particularly in the development of PROTACs (proteolysis-targeting chimeras). It contains a lenalidomide moiety, which binds selectively to CRBN, linked via a short PEG1 spacer to a terminal azide group. The azide handle enables efficient conjugation through click chemistry with alkyne-bearing ligands, linkers, or reporter groups, facilitating the construction of bifunctional molecules. The PEG1 spacer provides flexibility and solubility while minimizing steric hindrance. Lenalidomide-PEG1-azide is a valuable building block for medicinal chemistry, enabling precise design of CRBN-recruiting degraders and chemical biology probes.
| CAS Number | 2185795-67-7 |
| Synonyms | 2-(2-azidoethoxy)-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]acetamide |
| Molecular Formula | C17H18N6O5 |
| Purity | ≥95% |
| IUPAC Name | 2-(2-azidoethoxy)-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]acetamide |
| InChI | InChI=1S/C17H18N6O5/c18-22-19-6-7-28-9-15(25)20-12-3-1-2-10-11(12)8-23(17(10)27)13-4-5-14(24)21-16(13)26/h1-3,13H,4-9H2,(H,20,25)(H,21,24,26) |
| InChIKey | GGIQROQPJRHRQW-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3NC(=O)COCCN=[N+]=[N-] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
