Lenalidomide-I

• CAT Number: I045466
• CAS Number: 2207541-30-6
• Molecular Formula: C13H11IN2O3
• Molecular Weight: 370.14
• Purity: ≥95%
• Synonyms: 3-(7-iodo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
• InChI: InChI=1S/C13H11IN2O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6H2,(H,15,17,18)
• InChIKey: BKIUJJLYXXEGFT-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3I

Lenalidomide-I (Cat No.: I045466) is a functionalized derivative of lenalidomide in which the drug is modified with an iodine atom, enabling its use as a chemical probe or intermediate in targeted protein degradation and bioconjugation research. The lenalidomide moiety binds cereblon (CRBN), an E3 ubiquitin ligase substrate receptor, facilitating recruitment of target proteins for ubiquitination and proteasomal degradation in PROTAC designs. The iodine substituent allows further synthetic elaboration through cross-coupling reactions, making Lenalidomide-I a versatile building block in medicinal chemistry and chemical biology applications.

Reference

[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018
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