For research use only. Not for therapeutic Use.
Legumain Inhibitor 1（Cat No.:I044333）is a selective small-molecule inhibitor targeting legumain (asparaginyl endopeptidase), a lysosomal cysteine protease implicated in cancer progression, metastasis, and immune modulation. By blocking legumain activity, this inhibitor disrupts tumor-associated proteolysis and antigen processing, making it valuable for studying tumor microenvironment dynamics and immune responses. Legumain Inhibitor 1 has shown potential in preclinical cancer models, particularly in solid tumors with elevated legumain expression. It serves as a powerful tool for exploring protease function, cancer biology, and the development of targeted therapies involving lysosomal enzyme pathways.
| CAS Number | 2361157-34-6 |
| Synonyms | N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(1-methylindazol-5-yl)phenyl]sulfonylpropanamide |
| Molecular Formula | C23H25N5O4S |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2,2-dimethyl-3-[4-(1-methylindazol-5-yl)phenyl]sulfonylpropanamide |
| InChI | InChI=1S/C23H25N5O4S/c1-23(2,22(30)27-18(12-24)11-21(25)29)14-33(31,32)19-7-4-15(5-8-19)16-6-9-20-17(10-16)13-26-28(20)3/h4-10,13,18H,11,14H2,1-3H3,(H2,25,29)(H,27,30)/t18-/m0/s1 |
| InChIKey | VSSJIMWXYOLCSR-SFHVURJKSA-N |
| SMILES | CC(C)(CS(=O)(=O)C1=CC=C(C=C1)C2=CC3=C(C=C2)N(N=C3)C)C(=O)N[C@@H](CC(=O)N)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
