LDN-212854

For research use only. Not for therapeutic Use.

  • CAT Number: I001671
  • CAS Number: 1432597-26-6
  • Molecular Formula: C25H22N6
  • Molecular Weight: 406.5
  • Purity: ≥95%
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<p style=/line-height:25px/>LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.<br>IC50 value: 1.3 nM [1]<br>Target: ALK2<br>In vitro, LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity and function. LDN-212854 potently inhibits<br>heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.</p>


Catalog Number I001671
CAS Number 1432597-26-6
Molecular Formula C25H22N6
Purity ≥95%
Target TGF-βR1(ALK5)
Solubility DMSO: ≥ 30 mg/mL
Storage Store at -20°C
IC50 1.3 nM [1]
InChIKey BBDGBGOVJPEFBT-UHFFFAOYSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Mohedas AH, et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013;8(6):1291-302.
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