LDN-212854

• CAT Number: I001671
• CAS Number: 1432597-26-6
• Molecular Formula: C25H22N6
• Molecular Weight: 406.5
• Purity: ≥95%
• Target: TGF-βR1(ALK5)
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IC50: 1.3 nM [1]
• InChIKey: BBDGBGOVJPEFBT-UHFFFAOYSA-N

LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.IC50 value: 1.3 nM [1]Target: ALK2In vitro, LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity and function. LDN-212854 potently inhibitsheterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.

Reference

[1]. Mohedas AH, et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013;8(6):1291-302.