LDN-212854 - CAS 1432597-26-6

LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.
IC50 value: 1.3 nM [1]
Target: ALK2
In vitro, LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity and function. LDN-212854 potently inhibits
heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.

Catalog Number: I001671

CAS Number: 1432597-26-6

PubChem Substance ID:355049747

Molecular Formula: C25H22N6

Molecular Weight:406.5

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Molecular Formula: C25H22N6
Molecular Weight406.5
SolubilityDMSO: ≥ 30 mg/mL
StorageStore at -20°C
IC501.3 nM [1]

Computed Descriptor