For research use only. Not for therapeutic Use.
LDN-192960 hydrochloride（Cat No.:I018005）is a selective, ATP-competitive inhibitor of TAO kinases (TAOKs), which belong to the MAP kinase kinase kinase (MAP3K) family. By blocking TAOK activity, it disrupts downstream MAPK signaling cascades involved in cytoskeletal organization, stress responses, and cell survival. This compound is widely used in cancer and neurobiology research to probe TAOK-regulated pathways that influence tumor progression, apoptosis, and neuronal development. Its high potency and selectivity make LDN-192960 hydrochloride a valuable tool for studying kinase biology and evaluating therapeutic strategies targeting MAPK signaling.
| CAS Number | 2309172-48-1 |
| Synonyms | 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine;dihydrochloride |
| Molecular Formula | C18H22Cl2N2O2S |
| Purity | ≥95% |
| IUPAC Name | 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine;dihydrochloride |
| InChI | InChI=1S/C18H20N2O2S.2ClH/c1-21-12-4-6-16-14(10-12)18(23-9-3-8-19)15-11-13(22-2)5-7-17(15)20-16;;/h4-7,10-11H,3,8-9,19H2,1-2H3;2*1H |
| InChIKey | FNHCUCJBABESJB-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)N=C3C=CC(=CC3=C2SCCCN)OC.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
