LAURYL GLUCOSIDE

• CAT Number: M013181
• CAS Number: 110615-47-9
• Molecular Formula: C18H36O6
• Molecular Weight: 348.47
• Purity: ≥95%
• Synonyms: Dodecyl D-glucoside; lauryl glucoside; dodecyl d-glucopyranoside
• Storage: Desiccate at -20℃
• IUPAC Name: (3R,4S,5S,6R)-2-dodecoxy-6-(hydroxymethyl)oxane-3,4,5-triol
• InChI: 1S/C18H36O6/c1-2-3-4-5-6-7-8-9-10-11-12-23-18-17(22)16(21)15(20)14(13-19)24-18/h14-22H,2-13H2,1H3/t14-,15-,16+,17-,18?/m1/s1
• InChIKey: PYIDGJJWBIBVIA-IHAUNJBESA-N
• SMILES: CCCCCCCCCCCCOC1C(C(C(C(O1)CO)O)O)O

Lauryl glucose(CAT: M013181) is used as a surfactant. It has excellent decontamination, emulsification, solubilization, foaming, and foaming stability, which belongs to the mild surfactant. It has excellent compatibility with the skin and good flexibility for the hair. This product is used in the research field of color makeup and so on.

Reference

1. International journal of cosmetic science. A new formula for a mild body cleanser: sodium laureth sulphate supplemented with sodium laureth carboxylate and lauryl glucoside.2014 Aug;36(4):305-11. akagi Y, Shimizu M, Morokuma Y, Miyaki M, Kiba A, Matsuo K, Isoda K, Mizutani H.
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Objective
Sodium laureth sulphate (SLES) is an anionic detergent, which has been used globally for personal care products because of its mildness and good foaming ability. However, SLES is somewhat invasive and stimulatory to the skin, and many consumers with sensitive skin desire milder detergents for daily use skin cleansers. We enhanced the mildness of SLES by formulating it with sodium laureth carboxylate (AEC) and lauryl glucoside (LG).
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Methods
In skin soak tests, 5% detergent solutions were applied to the forearms of 10 Japanese healthy volunteers for 30 min followed by washing with tap water once a day for 4 days. Twenty‐four hours after the last treatment, cutaneous capacitance measurements and visual analyses were performed. In a controlled usage study, 16 Japanese healthy volunteers used the test body cleanser for 4 weeks. Assessment of efficacy and mildness was conducted prior to the start of the study and at the end of week 4 by cutaneous conductance, dermoscopic evaluation of the stratum corneum and visual assessment by a dermatologist.
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Results
In soak tests, cutaneous capacitance was significantly decreased on the soap‐treated region and on the SLES‐treated region. No significant decrease was identified on the SLES/AEC/LG‐treated region with less induction of erythema or dryness. In the controlled usage study, no significant changes in cutaneous conductance or texture or damage of corneocytes on the forearm and lower thigh were found. However, visual assessment revealed a significant decrease in scaling and erythema on the lower thigh after 4 weeks of usage with an improvement of the discomfort of the consumer. The favourability rating of this formulated detergent in several questionnaire items was very good.
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Conclusion
The newly formulated skin cleanser with the combination of anionic surfactants SLES and AEC and the non‐ionic surfactant LG provides a mild surfactant with a satisfactory cleansing activity for body washing.

 
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