Laurocapram

For research use only. Not for therapeutic Use.

  • CAT Number: M003208
  • CAS Number: 59227-89-3
  • Molecular Formula: C18H35NO
  • Molecular Weight: 281.48
  • Purity: ≥95%
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Laurocapram(Cat No.:M003208), also known as Azone, is a synthetic chemical penetration enhancer commonly used in topical pharmaceutical and cosmetic formulations. It is a lipophilic liquid with the molecular formula C₁₈H₃₅NO and appears as a clear, oily substance. Laurocapram enhances the permeability of active ingredients through the skin by disrupting the lipid structure of the stratum corneum. This property makes it valuable in transdermal drug delivery systems. It is generally well tolerated in topical use, though high concentrations may cause mild skin irritation. Proper formulation ensures both effectiveness and safety in dermal applications.

CAS Number 59227-89-3
Synonyms

hexahydro-n-lauryl-2h-azepin-2-on;n0252;n-laurylcaprolactam;tranzone;usafnd-72;AZONE;azon;LAUROCAPRAM

Molecular Formula C18H35NO
Purity ≥95%
Storage Store at -20°C
IUPAC Name 1-dodecylazepan-2-one
InChI InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3
InChIKey AXTGDCSMTYGJND-UHFFFAOYSA-N
SMILES CCCCCCCCCCCCN1CCCCCC1=O
Reference

<span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>1.<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Priborsk&yacute;, J., et al. &quot;Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Arzneimittel-forschung</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;42.2 (1992): 116-119.<br />
2.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>L&oacute;pez-Cervantes, Miriam, et al. &quot;Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Drug development and industrial pharmacy</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;32.3 (2006): 267-286.<br />
3.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Ogiso, Taro, et al. &quot;Enhancement of percutaneous absorption by laurocapram.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Journal of pharmaceutical sciences</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;81.8 (1992): 762-767.</span></span></span>

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