Latanoprost- CAS 130209-82-4


Latanoprost (CAS 130209-82-4) is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.

Catalog Number: A000003

CAS Number: 130209-82-4

PubChem Substance ID:347751602

Molecular Formula: C26H40O5

Molecular Weight:432.6

Purity: ≥95%

Online inquiry

* For research use only. Not for human or veterinary use.

Synonym

SynonymsPHXA41; PHXA-41; PHXA 41; XA34; XA-34; XA 34; Latanoprost, Xalatan, Catioprost

Property

Molecular Formula: C26H40O5
Molecular Weight432.6
Target:FP receptor
Solubility10 mM in DMSO
Purity≥95%
Storage-20°C
Overview of Clinical ResearchLatanoprost is a p<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;"><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">rostaglandin F2 alpha agonist developed by&nbsp;</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Kedalion Therapeutics.&nbsp;</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Kedalion Therapeutics planed a phase II trial&nbsp;</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">for Glaucoma in 2019.</span></span></span>

Computed Descriptor

IUPAC Namepropan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
InChIInChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InChIKeyGGXICVAJURFBLW-CEYXHVGTSA-N
SMILESCC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O