LAH5

• CAT Number: I040422
• CAS Number: 476169-12-7
• Molecular Formula: C132H224N40O27
• Molecular Weight: 2803.44
• Purity: ≥95%
• IUPAC Name: (2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoic acid
• InChI: InChI=1S/C132H224N40O27/c1-67(2)43-93(118(184)149-79(22)110(176)161-99(49-73(13)14)124(190)158-92(38-30-34-42-136)117(183)157-91(37-29-33-41-135)116(182)155-83(26)132(198)199)160-109(175)78(21)152-122(188)97(47-71(9)10)168-129(195)104(54-86-59-140-64-145-86)171-128(194)103(53-85-58-139-63-144-85)165-113(179)82(25)153-121(187)96(46-70(7)8)167-127(193)102(52-84-57-138-62-143-84)164-112(178)81(24)154-123(189)98(48-72(11)12)169-130(196)105(55-87-60-141-65-146-87)172-131(197)106(56-88-61-142-66-147-88)170-126(192)101(51-75(17)18)163-111(177)80(23)150-119(185)94(44-68(3)4)159-108(174)77(20)151-120(186)95(45-69(5)6)166-125(191)100(50-74(15)16)162-107(173)76(19)148-115(181)90(36-28-32-40-134)156-114(180)89(137)35-27-31-39-133/h57-83,89-106H,27-56,133-137H2,1-26H3,(H,138,143)(H,139,144)(H,140,145)(H,141,146)(H,142,147)(H,148,181)(H,149,184)(H,150,185)(H,151,186)(H,152,188)(H,153,187)(H,154,189)(H,155,182)(H,156,180)(H,157,183)(H,158,190)(H,159,174)(H,160,175)(H,161,176)(H,162,173)(H,163,177)(H,164,178)(H,165,179)(H,166,191)(H,167,193)(H,168,195)(H,169,196)(H,170,192)(H,171,194)(H,172,197)(H,198,199)/t76-,77-,78-,79-,80-,81-,82-,83-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-/m0/s1
• InChIKey: XIYLGLDUGIRSEK-VMWYSUIDSA-N
• SMILES: C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=CN=CN4)C(=O)N[C@@H](CC5=CN=CN5)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N

LAH5(CAT: I040422) is an amphipathic cell-penetrating peptide (CPP) engineered for efficient intracellular delivery of biomolecular cargo. It exhibits strong membrane affinity and endosomal escape capability, making it highly effective in transporting CRISPR-Cas9 ribonucleoprotein (RNP) complexes and RNP/HDR (homology-directed repair) templates into the nuclei of target cells. LAH5 forms stable nanocomplexes with its cargo, enabling precise gene editing with high delivery efficiency and low cytotoxicity. It is a valuable tool in genome engineering, gene therapy research, and molecular biology applications where non-viral, peptide-based delivery systems are desired. LAH5 supports advanced CRISPR workflows for functional genomics and therapeutic development.