Lactacystin (Synthetic) - CAS 133343-34-7

Lactacystin (Cat No.:R002306) is an antibiotic and a metabolite of Streptomyces spp. It is a potent and selective proteasome (protease) inhibitor with an IC50 of 4.8 μM for the 20S protease chemobook. lactacystin also inhibits the lysosomal enzyme histone A. lactacystin inhibits cell growth and induces neurosynaptic proliferation.

Catalog Number: R002306

CAS Number: 133343-34-7

PubChem Substance ID:355176461

Molecular Formula: C15H24N2O7S

Molecular Weight:376.424

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsN-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine; Lactacystin;

Property

Molecular Formula: C15H24N2O7S
Molecular Weight376.424
Target:Proteasome
SolubilitySoluble to 10 mM in sterile water
Purity≥95%
StorageStore at -20°C
MDLMFCD01076525

Computed Descriptor

IUPAC Name(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
InChIInChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
InChIKeyDAQAKHDKYAWHCG-RWTHQLGUSA-N
SMILESCC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O