Lactacystin (Synthetic) - CAS 133343-34-7
Lactacystin (Cat No.:R002306) is an antibiotic and a metabolite of Streptomyces spp. It is a potent and selective proteasome (protease) inhibitor with an IC50 of 4.8 μM for the 20S protease chemobook. lactacystin also inhibits the lysosomal enzyme histone A. lactacystin inhibits cell growth and induces neurosynaptic proliferation.
Catalog Number: R002306
CAS Number: 133343-34-7
PubChem Substance ID:355176461
Molecular Formula: C15H24N2O7S
Molecular Weight:376.424
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine; Lactacystin; |
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Property
Molecular Formula: | C15H24N2O7S |
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Molecular Weight | 376.424 |
Target: | Proteasome |
Solubility | Soluble to 10 mM in sterile water |
Purity | ≥95% |
Storage | Store at -20°C |
MDL | MFCD01076525 |
Computed Descriptor
IUPAC Name | (2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid |
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InChI | InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1 |
InChIKey | DAQAKHDKYAWHCG-RWTHQLGUSA-N |
SMILES | CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O |