For research use only. Not for therapeutic Use.
L0909(CAT: I030226) is a potent and orally available Hepatitis C virus (HCV) entry inhibitor with a novel mechanism of action. It effectively blocks HCV replication by targeting the viral entry stage, preventing the virus from infecting host cells. L0909 demonstrates strong antiviral activity with an EC₅₀ of 0.022 μM and a selectivity index (SI) > 600, indicating high potency and low cytotoxicity. Notably, L0909 shows high efficacy against clinically resistant HCV mutants and exhibits a synergistic effect when combined with existing antiviral drugs, making it a promising candidate for single-agent or combination therapy in HCV treatment.
| CAS Number | 2085271-43-6 |
| Synonyms | L0909; L-0909; L 0909 |
| Molecular Formula | C23H30ClN5 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile |
| InChI | InChI=1S/C23H30ClN5/c1-26(2)10-11-27(3)23-7-4-19(17-25)20(16-23)18-28-12-14-29(15-13-28)22-8-5-21(24)6-9-22/h4-9,16H,10-15,18H2,1-3H3 |
| InChIKey | ZMKYHHMOPNGIDE-UHFFFAOYSA-N |
| SMILES | N#CC1=CC=C(N(CCN(C)C)C)C=C1CN2CCN(C3=CC=C(Cl)C=C3)CC2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
