L-Threonine-13C4,15N

• CAT Number: I044980
• CAS Number: 202468-39-1
• Molecular Formula: 13C4H915NO3
• Molecular Weight: 124.08
• Purity: ≥95%
• Synonyms: (2S,3R)-2-(15N)azanyl-3-hydroxy(1,2,3,4-13C4)butanoic acid
• InChI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1/i1+1,2+1,3+1,4+1,5+1
• InChIKey: AYFVYJQAPQTCCC-KJQIOZMZSA-N
• SMILES: [13CH3][13C@H]([13C@@H]([13C](=O)O)[15NH2])O

L-Threonine-¹³C₄,¹⁵N（Cat No.:I044980）is a fully stable isotope-labeled essential amino acid, with all four carbon atoms enriched with carbon-13 and the nitrogen atom enriched with nitrogen-15. This isotopologue is widely used in tracer studies, metabolic flux analysis, and quantitative proteomics to investigate amino acid turnover, protein synthesis, and biosynthetic pathways. Its dual labeling enables precise detection via mass spectrometry and NMR, providing critical insights into nitrogen and carbon metabolism. L-Threonine-¹³C₄,¹⁵N is ideal for applications in systems biology, nutritional research, and isotopic labeling experiments.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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