L-AP6 - CAS 78944-89-5
L-AP6 (CAT: I010195) is an antagonist of the excitatory amino acid transporter subtype 3 (EAAT3), also known as glutamate transporter 1 (GLT-1). EAAT3 is a sodium-dependent transporter responsible for the reuptake of glutamate, an important neurotransmitter in the central nervous system. By inhibiting EAAT3, L-AP6 can interfere with glutamate reuptake, leading to increased extracellular levels of glutamate. This modulation of glutamate transport can have significant implications in neurobiological processes and neurodegenerative disorders. L-AP6 is commonly used in research to study the roles of glutamate transporters and glutamate signaling in various physiological and pathological conditions.
Catalog Number: I010195
CAS Number: 78944-89-5
PubChem Substance ID:355175791
Molecular Formula: C6H14NO5P
Molecular Weight:211.154
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | L-(+)-2-Amino-6-phosphonohexanoic acid |
|---|
Property
| Molecular Formula: | C6H14NO5P |
|---|---|
| Molecular Weight | 211.154 |
| Target: | GluR |
| Solubility | Soluble to 100 mM in 1eq. NaOH |
| Purity | ≥95% |
| Storage | Store at RT |
Computed Descriptor
| IUPAC Name | 2-amino-6-phosphonohexanoic acid |
|---|---|
| InChI | InChI=1S/C6H14NO5P/c7-5(6(8)9)3-1-2-4-13(10,11)12/h5H,1-4,7H2,(H,8,9)(H2,10,11,12) |
| InChIKey | QIOXWRQXHFVNLV-UHFFFAOYSA-N |
| SMILES | C(CCP(=O)(O)O)CC(C(=O)O)N |