L-AP6

  • CAT Number: I010195
  • CAS Number: 78944-89-5
  • Molecular Formula: C6H14NO5P
  • Molecular Weight: 211.154
  • Purity: ≥95%
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L-AP6 (CAT: I010195) is an antagonist of the excitatory amino acid transporter subtype 3 (EAAT3), also known as glutamate transporter 1 (GLT-1). EAAT3 is a sodium-dependent transporter responsible for the reuptake of glutamate, an important neurotransmitter in the central nervous system. By inhibiting EAAT3, L-AP6 can interfere with glutamate reuptake, leading to increased extracellular levels of glutamate. This modulation of glutamate transport can have significant implications in neurobiological processes and neurodegenerative disorders. L-AP6 is commonly used in research to study the roles of glutamate transporters and glutamate signaling in various physiological and pathological conditions.

Catalog Number I010195
CAS Number 78944-89-5
Synonyms

L-(+)-2-Amino-6-phosphonohexanoic acid

Molecular Formula

C6H14NO5P

Purity 95%
Target GluR
Solubility Soluble to 100 mM in 1eq. NaOH
Storage Store at RT
IUPAC Name 2-amino-6-phosphonohexanoic acid
InChI InChI=1S/C6H14NO5P/c7-5(6(8)9)3-1-2-4-13(10,11)12/h5H,1-4,7H2,(H,8,9)(H2,10,11,12)
InChIKey QIOXWRQXHFVNLV-UHFFFAOYSA-N
SMILES C(CCP(=O)(O)O)CC(C(=O)O)N

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