L-AP6 - CAS 78944-89-5

L-AP6 (CAT: I010195) is an antagonist of the excitatory amino acid transporter subtype 3 (EAAT3), also known as glutamate transporter 1 (GLT-1). EAAT3 is a sodium-dependent transporter responsible for the reuptake of glutamate, an important neurotransmitter in the central nervous system. By inhibiting EAAT3, L-AP6 can interfere with glutamate reuptake, leading to increased extracellular levels of glutamate. This modulation of glutamate transport can have significant implications in neurobiological processes and neurodegenerative disorders. L-AP6 is commonly used in research to study the roles of glutamate transporters and glutamate signaling in various physiological and pathological conditions.

Catalog Number: I010195

CAS Number: 78944-89-5

PubChem Substance ID:355175791

Molecular Formula: C6H14NO5P

Molecular Weight:211.154

Purity: ≥95%

* For research use only. Not for human or veterinary use.


SynonymsL-(+)-2-Amino-6-phosphonohexanoic acid


Molecular Formula: C6H14NO5P
Molecular Weight211.154
SolubilitySoluble to 100 mM in 1eq. NaOH
StorageStore at RT

Computed Descriptor

IUPAC Name2-amino-6-phosphonohexanoic acid