L-AP6

• CAT Number: I010195
• CAS Number: 78944-89-5
• Molecular Formula: C6H14NO5P
• Molecular Weight: 211.154
• Purity: ≥95%
• Synonyms: L-(+)-2-Amino-6-phosphonohexanoic acid
• Target: GluR
• Solubility: Soluble to 100 mM in 1eq. NaOH
• Storage: Store at RT
• IUPAC Name: 2-amino-6-phosphonohexanoic acid
• InChI: InChI=1S/C6H14NO5P/c7-5(6(8)9)3-1-2-4-13(10,11)12/h5H,1-4,7H2,(H,8,9)(H2,10,11,12)
• InChIKey: QIOXWRQXHFVNLV-UHFFFAOYSA-N
• SMILES: C(CCP(=O)(O)O)CC(C(=O)O)N

L-AP6 (CAT: I010195) is an antagonist of the excitatory amino acid transporter subtype 3 (EAAT3), also known as glutamate transporter 1 (GLT-1). EAAT3 is a sodium-dependent transporter responsible for the reuptake of glutamate, an important neurotransmitter in the central nervous system. By inhibiting EAAT3, L-AP6 can interfere with glutamate reuptake, leading to increased extracellular levels of glutamate. This modulation of glutamate transport can have significant implications in neurobiological processes and neurodegenerative disorders. L-AP6 is commonly used in research to study the roles of glutamate transporters and glutamate signaling in various physiological and pathological conditions.