L-838417-d9

• CAT Number: I006310
• CAS Number: 1213669-91-0
• Molecular Formula: C19H10D9F2N7O
• Molecular Weight: 408.45
• Purity: ≥95%
• Synonyms: 3-(2,5-difluorophenyl)-7-[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
• InChI: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3/i1D3,2D3,3D3
• InChIKey: BQDUNOMMYOKHEP-GQALSZNTSA-N
• SMILES: [2H]C([2H])([2H])C(C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F)(C([2H])([2H])[2H])C([2H])([2H])[2H]

L-838417-d9（Cat No.:I006310）is a deuterium-labeled analog of L-838417, a subtype-selective GABAA receptor modulator. It acts as a partial positive allosteric modulator at α2, α3, and α5 subunit-containing GABAA receptors while sparing the α1 subtype, which is typically associated with sedation. This selectivity makes it a promising candidate for anxiolytic and anticonvulsant effects with reduced sedative and addictive potential. The incorporation of nine deuterium atoms improves metabolic stability and allows for precise tracking in pharmacokinetic and receptor-binding studies, making L-838417-d9 valuable in neuroscience and drug development research.