For research use only. Not for therapeutic Use.
L-798106(CAT: R057597) is a potent and highly selective prostanoid EP3 receptor antagonist with a binding affinity of Ki = 0.3 nM. While primarily targeting EP3, it also exhibits weaker micromolar activity at other prostanoid receptors, including EP4 (Ki = 916 nM), EP1 (>5000 nM), and EP2 (>5000 nM). Functionally, L-798106 (200 nM) has been shown to inhibit electrical field stimulation–induced contractile responses, while at higher concentrations (10 μM) it reduces ACh release. In vivo, oral administration (50–100 μg/kg, once daily for 8 weeks) in db/db mice effectively suppresses systemic insulin resistance and adipose tissue inflammation, underscoring its therapeutic potential in metabolic disease research.
| CAS Number | 244101-02-8 |
| Synonyms | (E)-N-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide |
| Molecular Formula | C27H22BrNO4S |
| Purity | ≥95% |
| IUPAC Name | (E)-N-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide |
| InChI | InChI=1S/C27H22BrNO4S/c1-33-25-14-13-24(28)18-26(25)34(31,32)29-27(30)15-12-21-7-3-5-9-23(21)17-19-10-11-20-6-2-4-8-22(20)16-19/h2-16,18H,17H2,1H3,(H,29,30)/b15-12+ |
| InChIKey | ODTKFNUPVBULRJ-NTCAYCPXSA-N |
| SMILES | COC1=C(C=C(C=C1)Br)S(=O)(=O)NC(=O)C=CC2=CC=CC=C2CC3=CC4=CC=CC=C4C=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
