For research use only. Not for therapeutic Use.
L-741626(CAT: I007584) is a highly selective dopamine D₂ receptor antagonist with Ki values of 2.4 nM (D₂), 100 nM (D₃), and 220 nM (D₄), demonstrating strong subtype selectivity. Functional assays confirm its potency as a D₂ antagonist (EC₅₀ = 4.46 nM), with significantly lower activity at D₃ (EC₅₀ = 90.4 nM), yielding 15-fold D₃/D₂ and 136-fold D₄/D₂ selectivity. In vivo, L-741626 shifts pramipexole dose–response curves in D₂-mediated behavioral models and attenuates cocaine-induced neuroinflammatory responses by reducing microglial TNF-α production. With its high specificity, L-741626 is a valuable tool for neuropharmacological research on dopaminergic signaling, psychiatric disorders, and substance abuse.
| CAS Number | 81226-60-0 |
| Synonyms | 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol |
| Molecular Formula | C20H21ClN2O |
| Purity | ≥95% |
| IUPAC Name | 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol |
| InChI | InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2 |
| InChIKey | LLBLNMUONVVVPG-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CC3=CNC4=CC=CC=C43 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
