For research use only. Not for therapeutic Use.
L-692429 (CAT: I007558) is a benzolactam-derived, nonpeptidyl growth hormone secretagogue (GHS) receptor agonist with high affinity (Ki = 63 nM). It potently stimulates multiple signaling pathways, including intracellular calcium release (EC₅₀ = 26 nM), inositol phosphate turnover (EC₅₀ = 47 nM), CREB activation (EC₅₀ = 60 nM), SRE activity (EC₅₀ = 63 nM), and BRET response (EC₅₀ = 58 nM). In HeLa-T4 cells expressing GHS receptors, L-692429 induces calcium mobilization and luciferase activity, indicating MAPK pathway activation. In vivo, L-692429 promotes GH secretion in anesthetized rats, while its activity can be dose-dependently inhibited by the GHS receptor antagonist L-756867.
| CAS Number | 145455-23-8 |
| Synonyms | 3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide |
| Molecular Formula | C29H31N7O2 |
| Purity | ≥95% |
| IUPAC Name | 3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide |
| InChI | InChI=1S/C29H31N7O2/c1-29(2,30)17-26(37)31-24-16-15-21-7-3-6-10-25(21)36(28(24)38)18-19-11-13-20(14-12-19)22-8-4-5-9-23(22)27-32-34-35-33-27/h3-14,24H,15-18,30H2,1-2H3,(H,31,37)(H,32,33,34,35)/t24-/m1/s1 |
| InChIKey | SBJLJOFPWOYATP-XMMPIXPASA-N |
| SMILES | CC(C)(CC(=O)NC1CCC2=CC=CC=C2N(C1=O)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
