L-189

• CAT Number: I004427
• CAS Number: 64232-83-3
• Molecular Formula: C₁₁H₁₀N₄OS
• Molecular Weight: 246.29
• Purity: ≥95%
• Synonyms: (Z)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Target: DNA/RNA Synthesis
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20C
• IC50: 5/9/5 μM (for hLigI/III/IV)
• InChI: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)
• InChIKey: SAKOXVNKDMWWLF-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N

L-189 (Cat No.: I004427) is a synthetic compound known for its inhibitory activity against HIV-1 integrase, an essential enzyme for viral replication. By blocking the integration of viral DNA into the host genome, L-189 disrupts the HIV life cycle, making it a valuable lead compound in antiviral drug development. It has been used in early-stage research to explore integrase inhibition mechanisms and assess potential resistance profiles. L-189 contributes to the broader understanding of HIV biology and supports the advancement of targeted antiretroviral therapies.

Reference

[1]. Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008