Kynuramine dihydrochloride

• CAT Number: I045546
• CAS Number: 36681-58-0
• Molecular Formula: C9H14Cl2N2O
• Molecular Weight: 237.13
• Purity: ≥95%
• Synonyms: 3-amino-1-(2-aminophenyl)propan-1-one;dihydrochloride
• InChI: InChI=1S/C9H12N2O.2ClH/c10-6-5-9(12)7-3-1-2-4-8(7)11;;/h1-4H,5-6,10-11H2;2*1H
• InChIKey: GIUIHRRGPBPUAO-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)CCN)N.Cl.Cl

Kynuramine dihydrochloride (Cat No.: I045546) is a synthetic substrate commonly used for measuring monoamine oxidase (MAO) activity in biochemical assays. Upon oxidative deamination by MAO-A or MAO-B, kynuramine is converted into 4-hydroxyquinoline, a fluorescent product that enables sensitive detection of enzyme kinetics and inhibitor potency. Its high specificity and reproducibility make it an essential tool in neuropharmacology, enzymology, and drug discovery. Researchers employ Kynuramine dihydrochloride to study serotonin and dopamine metabolism, antidepressant mechanisms, and neurodegenerative disease pathways involving monoamine oxidases.

Reference

[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.
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[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6.
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[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51.
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[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.
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