For research use only. Not for therapeutic Use.
KY386(CAT: I040557) is a potent and selective inhibitor of the RNA helicase DHX33, exhibiting an IC₅₀ of 19 nM against the target enzyme. It demonstrates strong antiproliferative activity in U251-MG cells, a DHX33-overexpressing glioblastoma cell line, with a cellular IC₅₀ of 20 nM. KY386 disrupts DHX33-driven transcriptional regulation and ribosome biogenesis, leading to cell cycle arrest and apoptosis. With its potent anti-cancer effects and moderate metabolic stability, KY386 serves as a valuable chemical probe for studying DHX33 function in tumorigenesis. It is especially suited for preclinical cancer research aimed at developing RNA helicase-targeted therapies in aggressive and treatment-resistant cancers.
| CAS Number | 2787598-01-8 |
| Synonyms | 1-(3-cyano-5-methylthiophen-2-yl)-N-(6-methoxy-1H-benzimidazol-2-yl)-2,5-dimethylpyrrole-3-carboxamide |
| Molecular Formula | C21H19N5O2S |
| Purity | ≥95% |
| IUPAC Name | 1-(3-cyano-5-methylthiophen-2-yl)-N-(6-methoxy-1H-benzimidazol-2-yl)-2,5-dimethylpyrrole-3-carboxamide |
| InChI | InChI=1S/C21H19N5O2S/c1-11-7-16(13(3)26(11)20-14(10-22)8-12(2)29-20)19(27)25-21-23-17-6-5-15(28-4)9-18(17)24-21/h5-9H,1-4H3,(H2,23,24,25,27) |
| InChIKey | HGIMQJMGWCFYPE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(N1C2=C(C=C(S2)C)C#N)C)C(=O)NC3=NC4=C(N3)C=C(C=C4)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
