KY-226

• CAT Number: I017426
• CAS Number: 1621673-53-7
• Molecular Formula: C27H31NO3S2
• Molecular Weight: 481.67
• Purity: ≥95%
• IUPAC Name: N-hexylsulfonyl-4-[(4-phenylphenyl)methylsulfanylmethyl]benzamide
• InChI: InChI=1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)
• InChIKey: MKXMABKUVSOEJF-UHFFFAOYSA-N
• SMILES: CCCCCCS(=O)(=O)NC(=O)C1=CC=C(C=C1)CSCC2=CC=C(C=C2)C3=CC=CC=C3

KY-226(CAT: I017426) is a potent, selective, orally active, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 0.25 μM and no PPARγ agonist activity. By enhancing insulin and leptin signaling, KY-226 demonstrates strong anti-diabetic and anti-obesity effects. In vitro, it increases insulin-stimulated phosphorylation of insulin receptors in HepG2 cells and restores Akt/FoxO1 signaling and tight junction protein ZO-1 under inflammatory stress. In vivo, oral administration reduces plasma glucose, triglycerides, and HbA1c levels in db/db mice without affecting weight gain. KY-226 also protects neurons against cerebral ischemic injury, supporting its potential in metabolic and neurological disease research.