Kuraridine

• CAT Number: I045532
• CAS Number: 34981-25-4
• Molecular Formula: C26H30O6
• Molecular Weight: 438.51
• Purity: ≥95%
• Synonyms: (E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C26H30O6/c1-15(2)6-7-18(16(3)4)12-20-23(30)14-24(32-5)25(26(20)31)21(28)11-9-17-8-10-19(27)13-22(17)29/h6,8-11,13-14,18,27,29-31H,3,7,12H2,1-2,4-5H3/b11-9+/t18-/m1/s1
• InChIKey: PIAPWPAWQGDOMN-SXAWMYDMSA-N
• SMILES: CC(=CCC(CC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=C(C=C(C=C2)O)O)O)C(=C)C)C

Kuraridine (Cat No.: I045532) is a prenylated flavonoid isolated from plants of the Sophora genus, traditionally used in Asian herbal medicine. It exhibits a broad spectrum of bioactivities, including anti-inflammatory, antioxidant, antibacterial, and anticancer effects. Mechanistic studies suggest kuraridine can inhibit NF-κB signaling, suppress pro-inflammatory cytokines, and induce apoptosis in tumor cells. Its prenyl group enhances lipophilicity, improving interactions with biological membranes and targets. As a natural product lead, kuraridine is valuable in drug discovery, particularly for developing therapies against inflammation and cancer.

Reference

[1]. Hye Joo Shin, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.
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[2]. Xinzhou Yang, et al. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Mol Divers. 2011 May;15(2):361-72.
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