For research use only. Not for therapeutic Use.
KSC-34（Cat No.:I014814）is a potent and selective inhibitor of the deubiquitinating enzyme USP1, an important regulator of DNA damage repair and genomic stability. By blocking USP1 activity, KSC-34 disrupts the deubiquitination of FANCD2 and PCNA, thereby impairing the Fanconi anemia and translesion synthesis pathways. This inhibition sensitizes cancer cells to DNA-damaging agents, making KSC-34 a valuable compound for studying targeted therapeutic strategies in oncology. Its specificity provides an excellent tool for probing ubiquitin signaling, DNA repair mechanisms, and the development of novel anticancer drug combinations.
| CAS Number | 2226201-97-2 |
| Synonyms | 2-chloro-N-[2-[[4-[methyl(4-phenylbutyl)amino]-6-(prop-2-ynylamino)-1,3,5-triazin-2-yl]amino]ethyl]acetamide |
| Molecular Formula | C21H28ClN7O |
| Purity | ≥95% |
| IUPAC Name | 2-chloro-N-[2-[[4-[methyl(4-phenylbutyl)amino]-6-(prop-2-ynylamino)-1,3,5-triazin-2-yl]amino]ethyl]acetamide |
| InChI | InChI=1S/C21H28ClN7O/c1-3-12-24-19-26-20(25-14-13-23-18(30)16-22)28-21(27-19)29(2)15-8-7-11-17-9-5-4-6-10-17/h1,4-6,9-10H,7-8,11-16H2,2H3,(H,23,30)(H2,24,25,26,27,28) |
| InChIKey | QBGDVCZDAPRIMJ-UHFFFAOYSA-N |
| SMILES | CN(CCCCC1=CC=CC=C1)C2=NC(=NC(=N2)NCC#C)NCCNC(=O)CCl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
